Genotypic microbial community profiling: National Center for Biotechnology Information , U. Molecular methods have been largely used for profiling bacterial communities in diverse environments 16 , and one of their greatest advantages in this regard reside in the ability of including as-yet-uncultivated bacteria in the analysis Pseudoramibacter alactolyticus in primary endodontic infections. The apical root canal microbiota is predominantly anaerobic and the time of infection can influence this dominance, i.

Subramanian K, Mickel AK. In other words, while associations of any specific species with any form of apical periodontitis is seldom, if ever, observed, the bacterial community profiles seem to follow some patterns related to the different presentations of apical periodontitis The mysterious appearance of enterococci in filled root canals. In addition to bacteria, fungi and archaea have been only occasionally found in intraradicular infections 5 , 31 , 32 , while herpesviruses and HIV have been detected in apical periodontitis lesions 4 , 33 — As for flare-ups, the evidence of specificity is even weaker, although there are some reports of involvement of gram-negative anaerobes, such as black-pigmented rods and F. The amount of items that will be exported is indicated in the bubble next to export format.

Showing result 1 – 5 of 10 swedish dissertations containing the words apical periodontitis. On the use of denaturing gradient gel electrophoresis approach for bacterial identification in endodontic infections. Bacteria colonizing the root canal are usually organized in communities similar to biofilm structures. Thus, species prevalence and consequently only species association dossertation disease can be inferred from these studies.

The treatment usually requires 3 to 5 sessions. Again, identification of specific pathogen or molecular patterns related to treatment outcome may probably be the best way to establish tests to serve as a more accurate surrogate outcome.


Apical periodontitis is an inflammatory disease that affects the tissues surrounding the apical portion of the dental root and is primarily caused by microorganisms infecting the root canal 1 — 3. Molecular analysis of persistent periradicular lesions and sissertation ends reveals a diverse microbial profile.

Sobkowiak ; Karolinska Institutet.

Distinctive features of the microbiota associated with different forms of apical periodontitis

Table 1 summarizes the main features of the endodontic microbiota in different clinical conditions. Rapid quantitative profiling of complex microbial populations.

National epidemiologic data on oral health in children and adolescents in Sweden are restricted to caries, such as the number of decayed and filled teeth DFT and decayed and filled surfaces DFS.

Most of the cultivable named species found in extraradicular infections possess an array of virulence traits that may allow them to avoid or circumvent the host defenses in the inflamed periradicular tissues — Healing was determined using the periapical index. Variations in the susceptibilities of components of the endodontic microflora to biomechanical procedures.

dissertation apical periodontitis

Identification of Enterococcus faecalis in root-filled teeth with or without periradicular lesions by culture-dependent and -independent approaches.

Table 1 Distinctive features of the microbiota associated with different types of endodontic infections.

Distinctive features of the microbiota associated with different forms of apical periodontitis

Fusobacterium nucleatum Pseudoramibacter alactolyticus Filifactor alocis Fusobacterium nucleatum Prevotella spp. However, a recent apicaal using a histobacteriologic technique managed to detect bacteria in virtually all cases of post-treatment disease Search for dissertations about: The microbiota in root canal-treated teeth with post-treatment apical periodontitis also exhibits a decreased diversity both richness and abundance in comparison to primary infections.


Denaturing gradient gel electrophoresis analysis of bacterial communities associated with failed endodontic treatment. To export the items, click on the button corresponding with the preferred download format.

Please review our privacy policy. For instance, the acute apical abscess is usually dependent on the intraradicular infection, i. Several culture-difficult species have been consistently included in the set of candidate endodontic pathogens only diswertation the advent of molecular techniques for bacterial identification. Based on cross-sectional studies, several species djssertation emerged as candidate or putative endodontic pathogens, and the labels candidate or putative should be preserved while a definite role in disease causation is not determined.

These factors possibly include: Bacterial reduction in infected root canals treated with 2.


Apical actinomycosis, which is caused by Actinomyces species or P. However, limitations in culturing techniques, including low sensitivity and inability to detect as-yet-uncultivated bacteria, put the validity of its use as outcome predictor in question. Herpesviruses in endodontic pathoses: Light and electron microscopic studies of root canal flora and periapical lesions.

Therefore, the acute abscess can be regarded as an advanced stage of the acute disease. Even so, one can select 10—20 species that are virtually always among the most frequently detected species in most well-conducted studies about the endodontic microbiota.

dissertation apical periodontitis